Dr. Kristian G. Andersen
Dr. Kristian G. Andersen, Ph.D.
Postdoc
FAS Center for Systems Biology
Department of Organismic and Evolutionary Biology
Harvard University Northwest Building, Room 469
52 Oxford Street
Cambridge, MA 02138
kristian.andersen@vhfc.org
Bio
Kristian G. Andersen is a postdoctoral researcher at FAS Center for Systems Biology and Department of Organismic and Evolutionary Biology at Harvard University and the Broad Institute. Originally from Denmark, he received his PhD from the University of Cambridge and MRC Laboratory of Molecular Biology in 2009. Here, he worked on mechanisms of immunological tolerance and the evolution of the adaptive immune system.
Since moving to Harvard he has been investigating the complex relationship between host and pathogen. Using a combination of experimental and computational techniques he is investigating how the human immune system impacts the evolution of viral pathogens such as Lassa and Ebola. Given the strong selection pressures caused by these microorganisms, he is also investigating signals of natural selection in the human genome in response to infectious agents.
He was awarded the Carlsberg Foundation Scholarship from 2005-2008 and Postdoctoral Fellowship from 2009-2010. In 2008 he received the Max Perutz Prize for Outstanding Graduate Research.
Selected publications
- Genome-wide scans provide evidence for positive selection of genes implicated in Lassa fever
Andersen KG, Shylakhter I, Tabrizi S, Grossman SR, Happi CT, Sabeti PC
Philos Trans R Soc Lond B Biol Sci. 2012 Mar 19;367(1590):868-77 - Lassa hemorrhagic fever in a late term pregnancy from northern Sierra Leone with a positive maternal outcome: case report
Branco LM, Boisen ML, Andersen KG, Grove JN, Moses LM, Muncy IJ, Henderson LA, Schieffellin JS, Robinson JE, Bangura JJ, Grant DS, Raabe VN, Fonnie M, Zaitsev EM, Sabeti PC, Garry RF
Virol J. 2011 Aug 15;8:404 - Foxp3 Interacts with c-Rel to Mediate NF-κB Repression
Loizou L, Andersen KG, Betz AG
PLoS One. 2011 Apr 7;6(4):e18670 - Specific immunosuppression with inducible Foxp3-transduced polyclonal T cells
Andersen KG, Butcher T, Betz AG
PLoS Biol. 2008 Nov 11;6(11):e276 - Neuropilin-1 expression on regulatory T cells enhances their interactions with dendritic cells during antigen recognition
Sarris M, Andersen KG, Randow F, Mayr L, Betz AG
Immunity. 2008 Mar;28(3):402-13. Epub 2008 Mar 6 - Alloantigen-enhanced accumulation of CCR5+ 'effector' regulatory T cells in the gravid uterus
Kallikourdis M, Andersen KG, Welch KA, Betz AG
Proc Natl Acad Sci U S A. 2007 Jan 9;104(2):594-9 - LEF-1 negatively controls interleukin-4 expression through a proximal promoter regulatory element
Hebenstreit D, Giaisi M, Treiber MK, Zhang XB, Mi HF, Horejs-Hoeck J, Andersen KG, Krammer PH, Duschl A, Li-Weber M
J Biol Chem. 2008 Aug 15;283(33):22490-7