Dr. Virgil Woods

Virgil L. Woods, Jr., M.D

Professor of Medicine
School of Medicine, University of California, San Diego
9500 Gilman Drive, Room 4011
La Jolla, CA 92093
Phone: (858) 534-2180
Fax: (858) 534-2606
vwoods@ucsd.edu

Bio

Dr. Virgil Woods is a Professor of Medicine at the University of California, San Diego (UCSD). He is Chair of the Biomedical Sciences Graduate Program and Director of the UCSD DXMS Proteomics Resource.

The Woods laboratory provides the Consortium with access to Deuterium Exchange Mass Spectometry for analysis of crystallization constructs and antibody protein interfaces.

Selected publications

• Rapid refinement of crystallographic protein construct definition employing enhanced hydrogen/deuterium exchange MS
  Pantazatos D, Kim JS, Klock HE, Stevens RC, Wilson IA, Lesley SA, Woods VL Jr.
  Proc Natl Acad Sci U S A. 2004 Jan 20;101(3):751-6. Epub 2004 Jan 8.
• Protein structure change studied by hydrogen-deuterium exchange, functional labeling, and mass spectrometry
  Englander JJ, Del Mar C, Li W, Englander SW, Kim JS, Stranz DD, Hamuro Y, Woods VL Jr.
  Proc Natl Acad Sci U S A. 2003 Jun 10;100(12):7057-62. Epub 2003 May 28.
• Ebolavirus VP35 uses a bimodal strategy to bind dsRNA for innate immune suppression
  Kimberlin CR, Bornholdt ZA, Li S, Woods VL Jr, MacRae IJ, Saphire EO.
  Proc Natl Acad Sci U S A. 2010 Jan 5;107(1):314-9. Epub 2009 Dec 14.
• A phospholipid substrate molecule residing in the membrane surface mediates opening of the lid region in group IVA cytosolic phospholipase A2
  Burke JE, Hsu YH, Deems RA, Li S, Woods VL Jr, Dennis EA.
  J Biol Chem. 2008 Nov 7;283(45):31227-36. Epub 2008 Aug 27.
• Interaction of group IA phospholipase A2 with metal ions and phospholipid vesicles probed with deuterium exchange mass spectrometry
  Burke JE, Karbarz MJ, Deems RA, Li S, Woods VL Jr, Dennis EA.
  Biochemistry. 2008 Jun 17;47(24):6451-9. Epub 2008 May 24.
• PAS domain allostery and light-induced conformational changes in photoactive yellow protein upon I2 intermediate formation, probed with enhanced hydrogen/deuterium exchange mass spectrometry
  Brudler R, Gessner CR, Li S, Tyndall S, Getzoff ED, Woods VL Jr.
  J Mol Biol. 2006 Oct 13;363(1):148-60. Epub 2006 Aug 1.
• Distinct interaction modes of an AKAP bound to two regulatory subunit isoforms of protein kinase A revealed by amide hydrogen/deuterium exchange
  Burns-Hamuro LL, Hamuro Y, Kim JS, Sigala P, Fayos R, Stranz DD, Jennings PA, Taylor SS, Woods VL Jr.
  Protein Sci. 2005 Dec;14(12):2982-92. Epub 2005 Oct 31.
• Structure and properties of alpha-synuclein and other amyloids determined at the amino acid level
  Del Mar C, Greenbaum EA, Mayne L, Englander SW, Woods VL Jr.
  Proc Natl Acad Sci U S A. 2005 Oct 25;102(43):15477-82. Epub 2005 Oct 13.
• Structural determinants for generating centromeric chromatin
  Black BE, Foltz DR, Chakravarthy S, Luger K, Woods VL Jr, Cleveland DW.
  Nature. 2004 Jul 29;430(6999):578-82.
• Very late activation antigens (VLA) are human leukocyte-neuronal crossreactive cell surface antigens
  Pischel KD, Bluestein HG, Woods VL Jr.
  J Exp Med. 1986 Aug 1;164(2):393-406.
• IgD allotypic determinants. I. Determinants expressed on murine IgD of the a allotype.
  Woods VL Jr, Kessler SW, Finkelman FD, Lieberman R, Scher I, Paul WE.
  J Immunol. 1980 Dec;125(6):2699-707.